JCRMHS

  First line chemotherapy in metastatic colorectal cancers: A review by Alfredo Colombo in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract   A common malignancy that is detected is colorectal cancer (CRC). Unresectable, metastatic colorectal cancer (mCRC) patients have a poor prognosis and typically receive palliative care. Chemotherapy is the mainstay of therapy, but as molecular biology and its heterogeneity are better understood, the field is evolving. Depending on the clinical patient characteristics and tumor molecular profile, first-line therapy uses a combination of chemotherapy and targeted therapies. In this article, we examine the most recent data from randomized clinical trials supporting the use of chemotherapy triplets or doublets as well as the addition of bevacizumab or anti-epidermal growth factor receptor (EGFR) agents.  Introduction  One of the three cancer killers in developed countries is colorectal cancer (CRC), a ...

  Recanalized Umbilical Vein in a Patient with Cirrhosis by Dr. Sreeram Parupudi in Journal of Clinical Case Reports Medical Images and Health Sciences Clinical Image   41-year-old man with history of alcohol associated cirrhosis complicated by ascites presented with hematemesis. On admission he underwent a CT angiography which revealed portal hypertension manifested by a recanalized paraumbilical vein and portosystemic collaterals. EGD revealed Grade II esophageal varices and portal hypertensive gastropathy. A recanalized umbilical vein is a commonly reported finding on imaging in patients with portal hypertension and can be seen in up to 30% of patients with cirrhosis [1]. In adults without portal hypertension the umbilical vein is not visible and forms the round ligament [2]. Paraumbilical veins are collapsed veins found in the falciform ligament and connect to the left branch of the portal vein to the ventral abdominal veins that drain into the systemic circulation [2]. I...

  Gastric mucormycosis in a COVID-19 patient with severe lung involvement: a case report by Akbar Rasekhi Kazerouni  in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract  Background:  Mucormycosis (zygomycosis) is a rare opportunistic and life threatening infection that almost always affect immunocompromised patients. The Covid-19 associated mucormycosis is a new condition that has been described with high mortality rates. Gastrointestinal mucomycosis is a rare condition and stomach is the more common site in gastrointestinal mucomycosis.  Case presentation:  Presented case is a 41 year old cigarette smoker and diabetic man, who presented with Covid_19 lung involvement. Consequently, he developed with gastrointestinal bleeding and gastric mucormycosis was detected for him.  Conclusions:  Evaluating the clinical data and rare features of COVID-19 patients and studying the behavior of the disease is crucial for early dete...

 Serendipitous neurotransmitter findings in a frontline defender participating in a magnetic resonance spectroscopy study of first responders and military personnel with PTSD by David Crompton OAM in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract We report a case study of a patient with a clinical diagnosis of Post-traumatic Stress Disorder (PTSD) referred to a neurochemistry Magnetic Resonance Spectroscopy (MRS) study. The clinical evaluation prior to scanning suggested the presence of PTSD, Major Depressive Disorder (MDD) accompanied by suicidal ideation. MRS prior to and at the completion treatment and 12-weeks post treatment identified neurotransmitters consistent with a diagnosis of PTSD and MDD. The neurochemistry evaluation immediately post-treatment identified levels that compared to healthy subjects while at 12-weeks posttreatment the neurochemistry reflected a recurrence of depressive symptoms that were described by the patient. These resu...

 Integrating religious practices in psychotherapy? A Christian orthodoxic perspective by Frank-Gerald B. Pajonk in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract  Mental illnesses are related to the spiritual and religious dimensions of human experience. This has not yet been sufficiently taken into account in diagnostic and therapeutic processes. The aim of this overview is to show, on the basis of the rich tradition of the Christian Orthodox faith, not only that there is a history of Far Eastern provenance with regard to relaxation techniques and mental strategies, but also that the inclusion of spiritual and pastoral elements can help the individual patient to reach “peace of mind” (hesychia). Even severe psychiatric and psychosomatic illnesses, some of which are not always accessible through verbal and cognitive methods alone, can benefit from approaches to soul-spiritual concentration and ritual power such as the “Heart of Jesus Prayer”, bec...

 Hodgkin’s disease – Not Unknown Disease by Devershri Trivedi in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract  Hodgkin’s Lymphoma (HL) is a distinctive and highly manageable lymphoid neoplasm predominantly affecting the young adult population. In recent years, significant strides have been taken in comprehending the molecular underpinnings of HL and the development of innovative therapeutic modalities. This abstract provides an overview of recent advances in Hodgkin’s Lymphoma treatment, with a focus on promising therapeutic strategies and approaches. Advances in elucidating the molecular and genetic underpinnings of HL have led to the identification of novel therapeutic targets. Immune checkpoint inhibitors, including Pembrolizumab and Nivolumab, have demonstrated remarkable efficacy in cases of relapsed or refractory HL by reactivating the host’s immune response against malignant cells. Combinatorial approaches involving these agents and trad...