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Showing posts with the label Chemotherapy

First line chemotherapy in metastatic colorectal cancers: A review by Alfredo Colombo in Journal of Clinical Case Reports Medical Images and Health Sciences

  First line chemotherapy in metastatic colorectal cancers: A review by Alfredo Colombo in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract   A common malignancy that is detected is colorectal cancer (CRC). Unresectable, metastatic colorectal cancer (mCRC) patients have a poor prognosis and typically receive palliative care. Chemotherapy is the mainstay of therapy, but as molecular biology and its heterogeneity are better understood, the field is evolving. Depending on the clinical patient characteristics and tumor molecular profile, first-line therapy uses a combination of chemotherapy and targeted therapies. In this article, we examine the most recent data from randomized clinical trials supporting the use of chemotherapy triplets or doublets as well as the addition of bevacizumab or anti-epidermal growth factor receptor (EGFR) agents.  Introduction  One of the three cancer killers in developed countries is colorectal cancer (CRC), a ...